报道ＯＦ３对小鼠的急性毒性试验、微核试验，对大鼠骨髓染色体畸变及对大鼠的致畸试验的结果，小鼠经口ＬＤ５０为３３０ｇ／ｋｇ。其剂量在０１６－１６５ｇ／ｋｇ的微核试验结果表明：各剂量组与阴性对照组的微核率比较，结果无显著意义（Ｐ＞００５）；０３３－１６５ｇ／ｋｇ剂量组对大鼠的骨髓染色体畸变也无明显影响；致畸试验中随剂量的增大，母鼠的增长越缓慢。同时，鼠胎的体重也明显低于阴性对照组。提示：长期服用本品有减轻体重的作用，并对胚胎有一定的毒作用 Reported OF  3 in mice acute toxicity test, micronucleus test, chromosome aberration in rat bone marrow and teratogenicity test results in mice, mice oral LD50 was 3  30g / kg. The results of micronucleus test at 016-165 g / kg showed that there was no significant difference in micronucleus rate between each dose group and negative control group (P> 005); 033-1 65g / kg dose group had no significant effect on the chromosomal aberrations of bone marrow in rats. The increase of dose in the teratogenic test led to the slower growth of female rats. At the same time, the body weight of the mouse was also significantly lower than the negative control group. Tip: long-term use of this product has the role of weight loss, and the embryo has some toxic effects