【摘 要】
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Dear Editor,Type Ⅰ interferons (IFNs) are secreted in the context of viral infection and mediate the expression of more than 300 IFN-stimulated genes (Schoggin
【机 构】
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The Ministry of Education Key Laboratory of Protein Science, School of Life Sciences, Beijing Advanc
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Dear Editor,Type Ⅰ interferons (IFNs) are secreted in the context of viral infection and mediate the expression of more than 300 IFN-stimulated genes (Schoggins and Rice,2011).One of the earliest and most highly induced ISGs is IFN-stimulated gene 15 (ISG15),a ubiquitin-like protein (Ubl) comprising two Ubl domains connected by a linker (Farrell et al.,1979;Haas et al.,1987;Narasimhan et al.,2005).Similar to ubiquitin,ISG15 can be covalently attached to lysine on numerous target proteins via its C-terminal LRLRGG sequence in a process called ISGylation,which is catalyzed by the E1-activating enzyme Ube1L,the E2 conjugating enzyme UbcH8 and E3 ligases such as human HerC5 and mouse HerC6 (Hermann and Bogunovic,2016).
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