近年来国外发现参与Ⅱ类基因转录调控的启动子区也存在多态性，运用聚合酶链反应（ＰＣＲ）和末端终止法，对三个中国汉族人ＨＬＡ纯合细胞的ＤＱＡ１基因启动子区（ＱＡＰ）３１８ｂｐ的核苷酸（包括顺式作用元件Ｘ、Ｙ、Ｘ２和Ｗｂｏｘ）进行了扩增和测序，发现等位基因ＤＱＡ１＊０３０１１（纯合细胞ＳＭＹ２３Ａ）的ＱＡＰ结合和白种人的同一等位基因ＤＱＡ１＊０３０１１的ＱＡＰ不同，而与ＤＱＡ１＊０３０１２的ＱＡＰ结构相同，表明在ＤＱＡ１与ＱＡＰ之间可能发生了重组 In recent years, foreign countries found that there are polymorphisms in the promoter regions involved in the transcriptional regulation of class II genes. The polymerase chain reaction (PCR) and terminal termination methods were used to detect the DQA1 gene promoter region QAP) 318bp nucleotides (including cis-acting elements X, Y, X2 and Wbox) were amplified and sequenced and QAP binding of allele DQA1 * 03011 (homozygous SMY23A) was found to be identical to that of Caucasian The QAP of the allele DQA1 * 03011 is different from that of the QAP of DQA1 * 03012, indicating that recombination may occur between DQA1 and QAP