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多药耐药（MDR）是导致肿瘤化疗失败的主要原因之一，典型的MDR表型是由1型多药耐药基因（MDRl）过度表达介导的，其表达产物170KD的糖蛋白为ATP依赖性跨膜药物外排泵，通过降低组织细胞内药物积聚，从而使肿瘤对结构和作用机制完全不同的亲脂性药物产生交叉耐药。为了解药物耐
Multidrug resistance (MDR) is one of the main causes of failure of cancer chemotherapy. The typical MDR phenotype is mediated by the overexpression of type 1 multidrug resistance gene (MDR1). The expression product 170KD glycoprotein is ATP. Dependent transmembrane drug efflux pumps, through the reduction of intracellular drug accumulation in the tissue, make the tumor cross-resistance to lipophilic drugs with completely different structures and mechanisms of action. For drug resistance