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研究了二巯基丁二酸对铅的解毒作用。方法：小鼠iv210铅370kBq后，ig或ip二巯基丁二酸，剂量为1．0g·kg－1，用整体放射自显影术定位显示；大鼠210铅中毒后，用凝胶色谱法分离血清、肝、肾和尿，测定210铅与蛋白结合。结果：定位分布显示，对照小鼠肾脏210铅含量最高，肝、脾、肺、心、骨含量其次，脑内含量最低。给药后，大部分组织210铅含量明显减少。整体自显影片微光密度测定与相同部位组织用液门测定结果基本一致，大鼠血清和肝脏分离得到3个不同相对分子质量210铅蛋白复合物，肾脏仅有大分子210铅蛋白复合物，尿中主要为低相对分子质量非蛋白复合物。给药动物血清、肝脏和肾脏蛋白复合物与对照相似，但放射性含量低于对照，而尿中复合物210铅明显高于对照。结论：二巯基丁二酸对铅的解毒，减少了铅在体内各脏器中的沉积，以及与蛋白结合，促进其随尿液排出。
The detoxification of dimercaptosuccinic acid on lead was studied. METHODS: After mice iv 370 lead 370kBq, ig or ip dimercaptosuccinic acid at a dose of 1.0g · kg-1, the overall autoradiography localization; rat 210 lead poisoning after separation by gel chromatography Serum, liver, kidney and urine were assayed for 210 lead-protein binding. Results: Positioning distribution showed that the control mice had the highest lead content in the kidneys, followed by the content of liver, spleen, lung, heart and bone, and the lowest in the brain. After administration, lead levels in most tissues were significantly reduced. The integral self-developed film micro-optical density determination and the same site organization with the fluid door determination results are basically the same, the rat serum and liver were isolated three different molecular weight 210 lead protein complex, the kidneys only the 210 lead macromolecule complex, Urine is mainly low relative molecular mass non-protein complexes. Administration of animal serum, liver and kidney protein complexes with the control similar, but the radioactive content is lower than the control, while the urinary complex 210 lead was significantly higher than the control. Conclusion: Dimercaptosuccinate can detoxify lead, reduce the deposition of lead in various organs of the body, and bind with protein to promote its excretion with urine.