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大鼠皮下注射异丙肾上腺素(85mg/kg×2次,间隔24h)后,与对照组相比,血浆前激肽释放酶(PK)在首次注射后4h 即开始显著降低,24及48h 更低(P<0.05,<0.01);血浆 Fbg 在4、24及48h 呈进行性增高(P<0.01);血浆 AT-Ⅲ在4h 有下降趋势,24h 显著降低(P<0.01),48h恢复正常;凝血酶原时间(PT)在4h 显著延长(P<0.05),24及48h 转为显著缩短(P<0.01);凝血酶时间(TT)在4,24及48h 均表现为显著缩短(P<0.05);部分凝血活酶时间(APTT)在4h 有延长趋势,24h 显著缩短(P<0.01),48h 基本恢复正常.在24h 时,AT-Ⅲ与 PK 呈正直线性相关(γ=0.585,π=9),SGOT 和Ⅱ导联 ECG J/R 比值均与 PK 呈负直线性相关(γ分别为-0.604和-0.776,π=9).组织病理学检查发现,4及24h 大鼠心肌毛细血管内有血栓存在.提示大鼠皮下注射异丙肾上腺素后早期(4h 前)已有明显的凝血功能紊乱,主要表现为内源性凝血系统激活、血浆持续性高凝状态和血栓形成;这些变化可能是其心肌缺血发生的重要机理之一.
After rats were injected subcutaneously with isoproterenol (85 mg/kg×2 times, interval 24 h), plasma kallikrein (PK) began to decrease significantly at 4 h after the first injection, compared with the control group, at 24 and 48 h. Low (P<0.05, <0.01); Plasma Fbg was progressively increased at 4, 24, and 48h (P<0.01); Plasma AT-III was decreased at 4h, decreased significantly at 24h (P<0.01), and returned to normal at 48h. Prothrombin time (PT) was significantly prolonged at 4 h (P<0.05), significantly shortened at 24 and 48 h (P<0.01), and thrombin time (TT) was significantly shortened at 4, 24, and 48 h (P <0.05); Partial thromboplastin time (APTT) had a prolonged trend at 4h, significantly shortened at 24h (P<0.01), and basically returned to normal at 48h. At 24h, AT-III was positively correlated with PK (γ=0.585, π = 9), SGOT and II lead ECG J/R ratios were negatively correlated with PK (γ -0.604 and -0.768, π = 9). Histopathological examination found that 4 and 24h rat myocardium There were thrombi in the capillaries. It was suggested that early coagulation dysfunction occurred in rats (before 4h) after subcutaneous isoproterenol injection. The main manifestations were endogenous coagulation system activation, persistent hypercoagulability of plasma and thrombosis. These changes can be It is an important mechanism of myocardial ischemia occurs.