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目的 观察阿魏酸钠(SF)的抗心肌缺血的作用。方法 采用小鼠整体氧耗动态观察中分离心肌氧耗和垂体后叶素致家兔急性心肌缺血的方法。结果 ip.SF 0.3g/kg能明显降低小鼠心肌氧耗量,作用强度逊于阿替洛尔;iv.SF0.4g/kg可改变垂体后叶素致缺血心肌的心电图。结论 SF对缺血心肌有较好的保护作用。
Objective To observe the effect of sodium ferulate (SF) on myocardial ischemia. Methods The method of myocardial oxygen consumption and pituitrin induced acute myocardial ischemia in rabbits was observed by observing the global oxygen consumption of mice. Results ip.SF 0.3g/kg can significantly reduce the myocardial oxygen consumption in mice, and its effect is weaker than atenolol. iv.SF0.4g/kg can change the electrocardiogram of ischemic myocardium induced by pituitrin. Conclusion SF has a good protective effect on ischemic myocardium.