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目的探讨我国2001—2011年间出生缺陷的影响因素,为下一步的预防提供科学依据。方法利用Meta分析的方法系统评价2001—2011年间公开发表的有关我国出生缺陷影响因素的24篇文献。结果出生缺陷影响因素的合并比值比(OR值)及95%CI分别为孕期感冒发热2.00(1.46～2.73),孕期接触有害化学物质2.02(1.51～2.71),居住地有污染源1.86(1.26～2.73),孕期接触农药史1.80(1.08～2.99),孕期服用抗生素等药物1.65(1.37～1.98),自然流产史1.64(1.13～2.38),有生育畸形儿史1.61(1.30～2.01),父亲接触有害化学物质1.51(1.08～2.11),孕期弓形体病、其他病毒、风疹、巨细胞病毒、单纯疱疹病毒(TORCH)感染1.44(1.10～1.88),产次≥2次1.41(1.00～2.01),负性事件刺激1.11(1.04～1.19)。结论孕期感冒发热、孕期接触有害化学物质、孕期服用抗生素等药物、孕期负性事件刺激、孕期接触农药史、父亲接触有害化学物质、自然流产史、有生育畸形儿史、产次≥2次、居住地有污染源、孕期TORCH感染等是出生缺陷的影响因素。
Objective To explore the influencing factors of birth defects in China from 2001 to 2011, and provide scientific evidence for the next prevention. Methods Meta-analysis was used to systematically evaluate 24 published articles published in China from 2001 to 2011 on the influencing factors of birth defects in China. Results The combined odds ratio (OR) and 95% CI of the influencing factors of birth defects were 2.00 (1.46-2.73) during pregnancy, 2.02 (1.51-2.71) of exposure to harmful chemicals and 1.86 (1.26-2.73) ), The history of exposure to pesticides 1.80 (1.08 ~ 2.99), antibiotics and other drugs during pregnancy 1.65 (1.37 ~ 1.98), spontaneous abortion history 1.64 (1.13 ~ 2.38), with reproductive history 1.61 (1.30 ~ 2.01) (1.10 ~ 1.88), 1.41 (1.00 ~ 2.01) times of production of Toxoplasma gondii and other viruses, rubella, cytomegalovirus and herpes simplex virus (TORCH) Sexual events stimulated 1.11 (1.04 ~ 1.19). Conclusion Pregnancy, cold and fever, exposure to harmful chemicals during pregnancy, antibiotics and other drugs during pregnancy, pregnancy negative event stimulation, contact with pesticides during pregnancy, father exposure to harmful chemicals, spontaneous abortion history, history of reproductive malformations, the production times ≥ 2 times, There are sources of pollution, TORCH infection during pregnancy is the impact of birth defects.