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目的探讨16例鼻咽癌合并皮肌炎患者的放疗疗效及副作用情况。方法对16例鼻咽癌合并皮肌炎患者进行配对研究,比较两组生存率、急性及晚期放疗反应发生情况,探讨鼻咽癌合并皮肌炎患者的发病及治疗特点。结果16例鼻咽癌合并皮肌炎患者5年生存率为47%,与对照组相比无显著差异,皮肌炎组患者放疗中出现严重急性反应发生情况较对照组明显增加,晚期反应发生率无明显差别。结论鼻咽癌合并皮肌炎患者疗效与非皮肌炎患者相近,但放疗中出现较严重急性反应值得临床注意,大剂量激素治疗不需要常规使用。
Objective To investigate the radiotherapy efficacy and side effects of 16 patients with nasopharyngeal carcinoma and dermatomyositis. Methods 16 cases of nasopharyngeal carcinoma with dermatomyositis were paired study, survival rate, acute and late radiotherapy were compared between the two groups to explore the incidence and treatment of nasopharyngeal carcinoma patients with dermatomyositis. Results The 5-year survival rate of 16 patients with nasopharyngeal carcinoma complicated with dermatomyositis was 47%, which showed no significant difference compared with the control group. The incidence of severe acute reaction in patients with dermatomyositis was significantly higher than that of the control group and the late reaction occurred No significant difference in rates. Conclusions The efficacy of patients with nasopharyngeal carcinoma and dermatomyositis is similar to that of patients with non dermatomyositis. However, more serious acute reactions in radiotherapy are worthy of clinical attention. High-dose hormone therapy does not require routine use.