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最近发现氟哌酸对多种肠道致病菌包括霍乱弧菌高度敏感。本文作者应用氟哌酸、TMP-SMZ和安慰剂分别治疗脱水严重的霍乱患者,并进行疗效的比较评估。研究对象均为男性,年龄大于18岁,因急性水样腹泻和严重脱水(病程短于24小时)而入院。院外已用药物治疗或静脉补液的患者以及患有其他全身性疾病的患者除外。病人入院后均置于霍乱专用床上,根据WHO推荐的静脉输注乳酸林格氏溶液和口服补液溶液给予补液,询问病史,进行体检,
Norfloxacin has recently been found to be highly susceptible to a variety of enteric pathogens, including Vibrio cholerae. The authors applied norfloxacin, TMP-SMZ, and placebo, respectively, to treat patients with severe dehydration cholera and to evaluate their efficacy. Subjects were all men, over the age of 18, hospitalized for acute watery diarrhea and severe dehydration (duration less than 24 hours). Patients who have been hospitalized with drug therapy or intravenous fluids, as well as those with other systemic diseases, are excluded. After admission, the patients were placed on a bed dedicated to cholera. According to the WHO recommended intravenous infusion of lactated Ringer’s solution and oral rehydration solution for rehydration, medical history, physical examination,