自一九一九年Hurler首先对粘多糖病临床表现进行描述以来,报道日渐增多。我地区首次发现同胞兄弟两例,报道如下。 [例1]男,6岁,承德市双滦区偏桥子公社三家大队人。因5年来生长发育迟缓、头大、举止愚笨、智力落后、语言吐字不清,于8月20日入院。病儿为第一胎,足月顺产,2岁时能站立,2(1/2)岁会走。1岁以前未见异常。父母体健,非近亲结婚。其舅有类似病史,于10岁时夭 Since 1918 Hurler first described the clinical manifestations of mucopolysaccharides, reports have been increasing. Two cases of siblings were found in my area for the first time, as follows. [Example 1] Male, 6 years old, Shilan Sub-commune, Shuangluan District, Chengde City, three brigades. Due to growth retardation in 5 years, head big, stupid behavior, mental retardation, vomiting unclear language, admitted on August 20. Sick child as the first child, full-term spontaneous birth, 2 years old to stand, 2 (1/2) year-old will go. 1 year ago, no abnormalities. Parents healthy, non-relatives get married. His uncle have a similar history, died at the age of 10