应用手性固定相高效液相色谱对外消旋混合物进行光学活性拆分,具有快速、简便、效果好的优点。唐琴梅等制备了L-氨基酸酰氨型和L-二肽酰氨型固定相,对D、L-α一氨基酸和D、L-α-氨基膦酸的衍生物进行拆分,发现含芳环基团的化合物在手性柱上拆分效果较好,可能与芳环中含有六个π电子有关。N-乙酰基- Chiral stationary phase high performance liquid chromatography for the optical resolution of racemic mixtures is fast, simple and effective. Tang Qinmei et al prepared L-amino acid amide and L-dipeptidyl amide stationary phase, D, L-α amino acids and D, L-α-amino phosphonic acid derivatives were resolved and found to contain aromatic ring The resolution of the group of compounds on the chiral column is better, which may be related to the presence of six π electrons in the aromatic ring. N-acetyl-