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目的:观察携带乙型肝炎病毒的孕妇注射乙肝免疫球蛋白(HBIG)预防母婴宮內传播临床疗效?椒ǎ?对乙肝表面抗原阳性孕妇自孕28周起多次肌注HBIG60例为预防组及未注射的50例乙肝表面抗原阳性孕妇为对照组,采用酶联免疫法和荧光定量PCR法检测母血HBsAg及其新生儿血HBsAg、抗HBs、HBVDNA。结果:预防组60例新生儿中有54例血清抗HBs阳性与对照组相比差异有显著性(P<0.05),预防组新生儿血HBsAg、HBVDNA检出率均明显低于对照组。结论:经母亲对胎儿行被动免疫可有效预防乙肝病毒宫内传播。
Objective: To observe the clinical efficacy of hepatitis B immunoglobulin (HBIG) injection to prevent intrauterine transmission in pregnant women and infants by hepatitis B virus-infected pregnant women. And 50 non-injected pregnant women with hepatitis B surface antigen as control group. Serum HBsAg, anti-HBs and HBVDNA were detected by enzyme-linked immunosorbent assay and real-time PCR. Results: Among the 60 newborn infants in the prevention group, 54 cases had positive anti-HBs positive compared with the control group (P <0.05). The detection rates of HBsAg and HBVDNA in neonates with prevention group were significantly lower than those in the control group. Conclusion: Passive immunization of the fetus by mother can effectively prevent intrauterine transmission of hepatitis B virus.