论文部分内容阅读
本文研制了左旋18-甲基炔诺酮经皮吸收膜剂。采用HPLC法进行了膜剂的体外释放与渗透实验,结果表明药物的体外释放符合Higuchi方程,而经皮渗透则可用零级动力学加入表述。处方A经大鼠皮肤及人体皮肤的渗透速率分别为0.23,0.21 μg/cm~2/h。药物的体外释放和渗透受到多种处方因素的调节。处方A的体内研究证明,药物2 h内经皮吸收进入血液循环,逐渐达到200 pg/ml的峰值,并维持该血浓水平直到膜剂撕除。
This article developed a levonor 18-norgestrel percutaneous absorption of film. The in vitro release and permeation experiments were carried out by HPLC. The results showed that in vitro release of the drug was in accordance with the Higuchi equation, and transdermal penetration was expressed by zero-order kinetics. The permeation rates of prescription A on rat skin and human skin were 0.23 and 0.21 μg / cm ~ 2 / h, respectively. In vitro drug release and infiltration are regulated by a variety of prescription factors. In vivo studies of Formulation A demonstrated that the drug transdermally absorbed into the bloodstream within 2 h gradually reached a peak of 200 pg / ml and maintained the blood level until the membrane was torn off.