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目的对高血压患者卧位和立位的醛固酮/血浆肾素活性值(ARR)进行分析,探讨同一患者2种不同体位时ARR值的差异。方法应用放射免疫测定120例患者血浆肾素活性(PRA)和醛固酮(ALD),分别在卧位和立位采血测定血浆PRA和ALD,计算ARR值后进行分析。结果120例患者的卧位ARR值为(153.14±33.25),立位ARR值为(78.80±27.42)。样本ARR值经对数转换后符合正态分布。按α=0.05进行配对t检验,t=7.218,P<0.05,认为卧位和立位ARR对数值的分布差异有统计学意义。结论ARR值在立位和卧位时存在差异,应制定适用于不同体位的诊断标准。
Objective To analyze the aldosterone / plasma renin activity (ARR) values in supine and upright positions in hypertensive patients and to explore the differences in ARR values between two different positions in the same patient. Methods Serum renin activity (PRA) and aldosterone (ALD) were measured in 120 patients by radioimmunoassay. Plasma PRA and ALD were measured in the supine position and in the standing position respectively. ARR values were calculated and analyzed. Results The ARR of the 120 patients was 153.14 ± 33.25 and the ARR was 78.80 ± 27.42. The sample ARR values are lognormally converted to normal distribution. Paired t-test was performed at α = 0.05, t = 7.218, P <0.05. The distribution of ARR in supine position and standing position was considered statistically significant. Conclusion There is a difference in ARR between standing position and lying position. Diagnostic criteria applicable to different positions should be established.