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目的 :探讨肿瘤转移相关基因 CD44v6与甲状腺乳头状腺癌颈淋巴结转移及其生物学行为的关系。方法 :采用免疫组化 L SAB方法对 5 0例甲状腺乳头状腺癌存档标本进行 CD44v6表达测定。结果 :甲状腺乳头状腺癌颈淋巴结转移组 2 6例 CD44v6阳性表达率为 76 .9% (2 0 /2 6 ) ,颈淋巴结转移阴性组 2 4例中阳性率为 5 0 .0 % (1 2 /2 4) ,二者比较 P <0 .0 5 ;CD44v6表达阳性率与病人临床 T分期无明显相关性 (P >0 .0 5 )。结论 :CD44v6表达与甲状腺乳头状腺癌的颈淋巴结转移密切相关 ,对预测颈淋巴结转移的危险性有一定参考价值。
Objective: To investigate the relationship between CD44v6 gene and cervical lymph node metastasis and its biological behavior in papillary thyroid carcinoma. Methods: Immunohistochemical L SAB method was used to detect the expression of CD44v6 in 50 specimens of thyroid papillary adenocarcinoma. Results: The positive rate of CD44v6 in 26 cases with cervical lymph node metastasis of thyroid papillary adenocarcinoma was 76.9% (20/26), and the positive rate was 50.0% (1) in 24 cases with negative cervical lymph node metastasis 2/2 4). There was no significant correlation between the positive rate of CD44v6 expression and clinical stage of T (P> 0.05). Conclusion: The expression of CD44v6 is closely related to the cervical lymph node metastasis of papillary thyroid carcinoma, which is of certain reference value for predicting the risk of cervical lymph node metastasis.