论文部分内容阅读
随着对慢性阻塞性肺疾病(COPD)研究的不断深入,COPD后期肺间质纤维化(PIF)的改变逐渐取代了肺气肿的固有变化的现象引起学者们的注意,使以往认为COPD与PIF是两种相互独立、不能共存的疾病类型的观点发生改变。双重的病理改变势必更加严重的破坏肺组织结构,造成严重缺氧和弥散功能障碍,使COPD病情恶化加速,目前这已经成为临床上所面临的一个难题,早期诊断和恰当的治疗仍可望改善患者的生活质量和延长生存期。本文报告了PIF合并COPD的流行病学特征、发病机制、诊断、治疗方面的研究现状从而深化认识,为临床提供预防、诊断及抗炎抗纤维化治疗的新思路。
With the deepening of the study on chronic obstructive pulmonary disease (COPD), the change of pulmonary interstitial fibrosis (PIF) in the late stage of COPD gradually replaced the inherent change of emphysema and attracted the attention of scholars. In the past, COPD and The idea that PIF is a type of disease that is independent of each other and can not coexist has changed. Dual pathological changes are bound to be more serious damage to lung tissue structure, causing severe hypoxia and diffuse dysfunction, accelerated exacerbations of COPD, which has now become a clinical challenge, early diagnosis and appropriate treatment is still expected to improve Patient’s quality of life and prolonging survival. This article reports on the epidemiological characteristics, pathogenesis, diagnosis and treatment of COPD in PIF combined with PIF to deepen our understanding and provide new ideas for the prevention, diagnosis and anti-inflammatory anti-fibrosis treatment in clinic.