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小白鼠口服抗疟药复方硝喹,ED_(50)为0.18±0.01mg/kg,与已知几种抗疟药的比,疗效最高,化疗指数最大(1911)。狗服复方硝喹对肾上腺皮质的毒性反应与服单方相仿,但血中高铁血红蛋白含量则服复方硝喹后有明显升高。服较大的中毒剂量(50mg/kg/日×3)时同时肌注叶酸或甲酰四氢叶酸钙可明显降低狗的死亡率和腹泻发生率,病理组织学检查,小肠病变明显减轻,粘膜上皮杯状细胞显著增多。提示用叶酸或甲酰四氢叶酸钙后能保护复方硝喹对小肠的破坏,因而会大大减轻其临床毒性反应。
The oral compound anti-malaria compound oral nitroquine (ED50) was 0.18 ± 0.01mg / kg. Compared with several known anti-malarial drugs, the efficacy of the compound was the highest and the chemotherapy index was the highest (1911). Dog clothes compound nitroglycerin on the adrenal cortex toxicity and service unilateral similar, but the blood methemoglobin content of the compound was significantly increased after Quinquium. Taking larger dose (50mg / kg / day × 3), intramuscular folic acid or leucovorin at the same time can significantly reduce the incidence of dog’s mortality and diarrhea. Pathological examination, pathological changes of intestinal tract and mucosa Epithelial goblet cells increased significantly. Prompt folic acid or folinic acid calcium folic acid compound can protect the small intestine after the destruction of nitrate, which will greatly reduce the clinical toxicity.