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目的:观察内界膜剥除联合玻璃体内注射曲安奈德治疗弥漫性糖尿病性黄斑水肿(DME)的疗效。方法:回顾性分析郑州市第二人民医院2017年5月至2019年12月弥漫性DME 56例(56眼)的临床资料。根据不同方法将患者分为两组：内界膜剥除联合玻璃体内注射曲安奈德为A组，28例(28眼)；单纯内界膜剥除为B组，30例(30眼)。比较两组治疗后视力及黄斑中心区厚度(CMT)。结果:A组CMT降低明显，视力提高快，平均CMT及视力与术前比较差异均有统计学意义(n P0.05)，术后1、3及6个月CMT逐渐降低(n P<0.05)。组间比较：术后2周及1个月A组视力及CMT均优于B组(n P0.05)。n 结论:对于弥漫性DME，内界膜剥除术安全有效，联合玻璃体腔内注射曲安奈德能加速黄斑水肿消除及视力提高。“,”Objective:To observe the efficacy of internal limiting membrane peeling combined with triamcinolone acetonide for the treatment of diffuse diabetic macular edema.Methods:The clinical data of 56 eyes 56 of cases of diffuse diabetic macular edema from May 2017 to Dec. 2019 in Zhengzhou Municipal Second People’s Hospital were analyzed retrospectively.The patients were divided into two groups based on different methods.The group A, 28 eyes of 28 cases, received internal limiting membrane peeling combined with intravitreal injection of triamcinolone acetonide. The group B, 30 eyes 30 cases, received simple internal limiting membrane peeling.The visual acuity and central macular thickness(CMT) between the two groups after operation were compared.Results:The CMT in group A decreased significantly, and the visual acuity improved rapidly. The difference of average CMT and visual acuity were statistically significant before and after operation (n P0.05). The CMT decreased gradually at 1 month, 3 months, and 6 months after operation(n P<0.05). The visual acuity and CMT in the group A were better than that in the group B at 2 weeks and 1 month after operation (n P0.05).n Conclusion:Internal limiting membrane peeling is safe and effective for the treatment of diffuse diabetic macular edema, which combined with intravitreal injection of triamcinolone can accelerate the elimination of macular edema and improve vision.