溶组织内阿米巴(E.h.)引起人体阿米巴病——阿米巴痢疾和肝脓肿。感染后滋养体增殖是其致病的主要原因,在滋养体增殖的同时,DNA在肠内或肝内合成,在这方面DNA聚合酶起决定性作用。本文作者以前曾报告了E.h.核提取物DNA聚合酶为aphidicolin所抑制。Aphidicolin是头孢菌属Cephalosporium aphidicola等所产生的真菌毒素,已知它是一种特异的真核生物细胞核 E. histolytica causes human amebiasis-amoebic dysentery and liver abscess. Trophoblast proliferation after infection is the main reason for its pathogenicity, proliferation of trophozoites at the same time, DNA synthesis in the intestine or liver, in this regard DNA polymerase plays a decisive role. The authors of this paper previously reported that E. nuclear extract DNA polymerase is inhibited by aphidicolin. Aphidicolin is a mycotoxin produced by Cephalosporium aphidicola and is known to be a specific eukaryotic nucleus