五氧化二钒(V_2O_5)是常见的吸入性工业毒物,对钒作业工人有一定毒害作用。为探讨钒对氨基酸代谢影响,我们对正常人和接钒工人的血清、尿、毛发中氨基酸进行检测。其中不接钒者男性12人,平均年龄43岁(37～56岁);接钒者为某铁合金厂钒铁车间的焙烧、电冶工序12人,均男性,平均年龄43岁(37～56岁),工龄20～28年。氨基酸测定方法按文献。结果车间空气中钒浓度1.2～18.0mg/m~3,平均10.3mg/m~3。超过国家最高容许浓度百余倍,未测出氨和二氧化硫。接钒组尿钒含量为76.5±46.8nmol/gGr。接钒组血清胱氨酸、酪氨酸含量低于对照组,经t检验差异显著(P<0.05)。尿中苯丙氨酸含量与对 Vanadium pentoxide (V_2O_5) is a common inhalational industrial toxicants, vanadium workers have some toxic effects. To investigate the effect of vanadium on amino acid metabolism, we detected amino acids in serum, urine, and hair of normal and vanadium-receiving workers. Including vanadium were 12 males, average age 43 years (37 to 56 years old); vanadium was a ferro-alloy plant vanadium iron plant roasting, electrofining process 12 people, both men, mean age 43 years (37 ~ 56 Years old), 20 to 28 years of service. Amino acid determination method according to the literature. Results Workshop vanadium concentration of 1.2 ~ 18.0mg / m3, an average of 10.3mg / m3. More than a hundred times the national maximum allowable concentration, did not detect ammonia and sulfur dioxide. Vanadium vanadium group was 76.5 ± 46.8nmol / gGr. The contents of serum cystine and tyrosine in the group receiving vanadium were lower than that in the control group, and the difference was significant by t test (P <0.05). Urine phenylalanine content and right