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目的探讨溶血磷脂酸(LPA)在上皮性卵巢癌诊断及病情监测中的价值。方法选择2005年4月至10月河北医科大学第四医院收治的40例初治上皮性卵巢癌患者,测定其术前和术后的血浆LPA和CA125,同时测定其中20例腹水中的LPA,并选择同期20例良性卵巢肿瘤患者血浆和腹腔冲洗液作对照。结果上皮性卵巢癌组术前血浆LPA明显高于良性对照组(P<0·01),且术后水平低于术前(P<0·01)。上皮性卵巢癌患者腹水LPA明显高于良性卵巢肿瘤患者腹腔冲洗液(P<0·01)。LPA诊断Ⅰ期上皮性卵巢癌的敏感性及特异性分别是75%和80%。CA125的敏感性及特异性分别是25%和40%。结论LPA升高可能成为早期上皮性卵巢癌诊断的新的生物学指标,同时可监测病情并判断病人的预后。
Objective To investigate the value of lysophosphatidic acid (LPA) in the diagnosis and disease surveillance of epithelial ovarian cancer. Methods Forty patients with primary epithelial ovarian cancer who were admitted to the Fourth Hospital of Hebei Medical University from April to October 2005 were enrolled in the study. Preoperative and postoperative plasma LPA and CA125 levels were measured. LPA, And select the same period in 20 cases of benign ovarian tumors in patients with plasma and peritoneal lavage fluid control. Results The preoperative plasma LPA in epithelial ovarian cancer group was significantly higher than that in benign control group (P <0.01), and the postoperative level was lower than preoperative (P <0.01). LPA in ascites from patients with epithelial ovarian cancer was significantly higher than that from patients with benign ovarian cancer (P <0.01). The sensitivity and specificity of LPA in the diagnosis of stage I epithelial ovarian cancer are 75% and 80%, respectively. The sensitivity and specificity of CA125 are 25% and 40% respectively. Conclusions The elevated LPA may be a new biological indicator for the diagnosis of early stage epithelial ovarian cancer. Meanwhile, it can monitor the condition and judge the prognosis of patients.