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Atrial natriuretic peptide (ANP) is a kind of polypeptide hormones secreted fromheart myocytes which is isolated by De Bold in 1981. ANP possesses diuretic,natriuretic, and hypotensive activities and inhibits renin-angiotensin-aldosterone system(RAA).α-ANP (99—126) consists of 28 amino acids and a disulfide bond linking Cysand Cys forms a cyclic core which comprises 17 residues. ANPs of different species arealmost identical. The only difference between α-hANP and α-rANP occurs at position 110where Met is for hANP while He is for rANP. rAPⅢ (103—126) (rat atriopeptin) is ashort natural form of rANP and has rather potent activities.
Atrial natriuretic peptide (ANP) is a kind of polypeptide hormones secreted from heart myocytes which is isolated by De Bold in 1981. ANP possesses diuretic, natriuretic, and hypotensive activities and inhibits renin-angiotensin-aldosterone system (RAA) -126) consists of 28 amino acids and a disulfide bond linking Cys and Cys forms a cyclic core which comprise 17 residues. ANPs of different species are almost identical. The only difference between α-hANP and α-rANP occurs at position 110 where Met is for hANP while He is for rANP. rAPIII (103-126) (rat atriopeptin) is ashort natural form of rANP and has rather potent activities.