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支气管哮喘(简称哮喘)是一种以Th1/Th2免疫失衡、Th2优势应答为特征的慢性气道炎症性疾病。细胞因子信号转导抑制因子3(SOCS-3)是一类与细胞因子JAK/STAT信号转导途径有关的负反馈调节因子,参与细胞固有免疫、获得性免疫和炎症反应。近年来研究发现,在哮喘的发生发展中SOCS-3均表现出分子水平或功能的异常,揭示SOCS-3可作为哮喘诊断和治疗的新靶点。就SOCS-3与哮喘的关系研究进展进行综述,讨论其在哮喘Th1/Th2免疫失衡中的作用。
Bronchial asthma (asthma) is a chronic airway inflammatory disease characterized by a Th1 / Th2 immune imbalance and a Th2 predominant response. Cytokine signal transduction inhibitor 3 (SOCS-3) is a class of negative feedback regulators associated with the cytokine JAK / STAT signaling pathway involved in cellular innate immunity, adaptive immunity and inflammatory responses. In recent years, the study found that SOCS-3 showed abnormal molecular level or function in the development and progression of asthma, revealing SOCS-3 as a new target for the diagnosis and treatment of asthma. The progress of research on the relationship between SOCS-3 and asthma is reviewed, and its role in immune imbalance of Th1 / Th2 in asthma is discussed.