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目的探讨血尿淀粉酶及尿胰蛋白酶原-2检测对急性胰腺炎的早期诊断和治疗的临床意义。方法收集急腹症患者217例的血清和尿液标本,分别检测其尿胰蛋白酶原-2与血、尿淀粉酶活性,并比较其在急性胰腺炎诊断中的特异度与敏感度。结果 217例中临床确诊急性胰腺炎84例,尿胰蛋白酶原-2检测敏感度为92.9%,特异度为96.2%;血淀粉酶敏感度为83.3%,特异度为82.0%;尿淀粉酶敏感度为84.5%,特异度为81.2%。结论尿胰蛋白酶原-2在急性胰腺炎诊断中的敏感度和特异度均高于血、尿淀粉酶,三项联合检测有利于减少急性胰腺炎的误漏诊。
Objective To investigate the clinical significance of hematuria amylase and urinary trypsinogen-2 in the early diagnosis and treatment of acute pancreatitis. Methods Serum and urine samples from 217 patients with acute abdomen were collected and their urinary trypsinogen-2, amylase and urine amylase activity were tested. The specificity and sensitivity of the method were compared in the diagnosis of acute pancreatitis. Results Among the 217 cases, 84 cases of acute pancreatitis were clinically diagnosed. The urinary trypsinogen-2 detection sensitivity was 92.9% and the specificity was 96.2%. The amylase sensitivity of blood amylase was 83.3% and the specificity was 82.0% The degree was 84.5% and the specificity was 81.2%. Conclusions The sensitivity and specificity of urinary trypsinogen-2 in the diagnosis of acute pancreatitis are higher than those of blood and urine amylase. The three combined tests are helpful to reduce the misdiagnosis of acute pancreatitis.