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探讨32P-玻璃微球（32P-GMS）局部注射对裸鼠人肝癌移植瘤的治疗作用和超微结构影响。建立裸鼠人肝癌移植瘤模型后用32P-GMS进行治疗，取治疗后瘤组织用透射电镜观察。结果：实验组癌细胞大量坏死（35％～70％），残留的瘤细胞在分化上出现了一些差异，部分癌细胞出现了高分化肝癌的形态特征；肿瘤间质见淋巴细胞浸润和纤维结缔组织增生，但无强烈的急性放射性炎反应；瘤体周围肌纤维和皮肤均无改变。对照组肿瘤示低分化肝癌，其中有少量死亡瘤细胞（4％）。研究表明，32P-GMS抗肝癌作用明显，并有一定的免疫调节和促分化功能，对治疗区周围组织亦无损伤。
To investigate the effect of 32P-GMS injection on human hepatocellular carcinoma xenografts in nude mice and its ultrastructural effects. The human hepatoma transplanted tumor model of nude mice was established and treated with 32P-GMS. The treated tumor tissues were observed by transmission electron microscopy. RESULTS: A large number of necrotic cells (35% to 70%) were found in the experimental group. The residual tumor cells showed some differences in their differentiation. Some of the cancer cells showed the morphological characteristics of well-differentiated liver cancer. Lymphocytic infiltrates and fibrous connectives were found in the tumor interstitium. Tissue hyperplasia, but no acute, acute radio-inflammatory reactions; no changes in the surrounding muscle fibers and skin. The control group of tumors showed poorly differentiated liver cancer, with a small number of dead tumor cells (4%). Studies have shown that 32P-GMS has significant anti-hepatocarcinoma effects, and has certain immunoregulatory and pro-differentiation functions, and no damage to the surrounding tissues of the treated area.