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文章简介树突棘是兴奋性突触的突触后结构,在发育过程中呈现动态变化,包括出生后早期的快速树突棘生长和青少年期的树突棘修剪。树突棘修剪的异常与孤独症等发育性神经系统疾病相关,但介导这一过程的分子机制尚不清楚。本研究发现,在小鼠躯体感觉皮层,树突棘的修剪与成熟在cadherin/catenin细胞粘附复合物的介导下协同进行,并且受感觉经验的双向调控。进一步研究发现,在单个树突棘的水平局部增加cadherin/catenin依赖的粘附作用,能够稳定被操纵的树
Introduction The dendritic spine is a post-synaptic structure of excitatory synapses that exhibits dynamic changes during development, including rapid dendritic spine growth in early postnatal days and dendritic spine pruning in adolescence. Abnormalities in dendritic spine pruning are associated with developmental neurological disorders such as autism, but the molecular mechanisms underlying this process are not yet clear. The present study found that in the somatosensory cortex of mice, the pruning and maturation of dendritic spines are synergistically mediated by the cadherin / catenin cell adhesion complex and are bi-directionally regulated by sensory experience. Further studies have found that local elevation of cadherin / catenin-dependent adhesion at the level of a single dendritic spine can stabilize the tree being manipulated