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目的:测定血浆和肽素(copeptin)在急性心肌梗死(AMI)组患者中的浓度变化以及与冠脉病变的关系。方法:对2010年1月～12月我院因胸部不适收治的疑是AMI的患者110例,采用ELISA分析法检测血浆copeptin水平,用固定层析免疫法测定肌钙蛋白、肌酸激酶同工酶(CK-MB)水平。结果:AMI组患者血浆copeptin水平显著高于不稳定心绞痛组和非冠心病组(P<0.01);AMI患者copeptin浓度随着出现症状时间的增加而下降,而肌钙蛋白、CK-MB浓度随着临床症状出现时间的增加而升高;3支病变Copeptin水平明显高于与1、2支病变组。结论:早期测定血浆copeptin水平对于怀疑为AMI患者的诊断具有重要临床意义,且升高程度可反映冠状动脉病变严重程度。
Aims: To determine the plasma concentrations of copeptin in patients with acute myocardial infarction (AMI) and its relationship with coronary artery disease. Methods: From January to December 2010 in our hospital because of chest discomfort were suspected of AMI in patients with 110 cases, the plasma levels of copeptin were measured by ELISA, and the serum levels of troponin and creatine kinase Enzyme (CK-MB) levels. Results: The plasma levels of copeptin in patients with AMI were significantly higher than those in patients with unstable angina and non-coronary heart disease (P <0.01). The copeptin concentrations in AMI patients decreased with the increase of symptoms time, while the concentrations of troponin and CK-MB The onset time of clinical symptoms increased and the level of Copeptin in 3 lesions was significantly higher than that in 1 and 2 lesions. Conclusion: The early determination of plasma copeptin levels has important clinical significance for the diagnosis of patients with suspected AMI, and the degree of increase reflects the severity of coronary artery disease.