肝肾综合征(hepatorenalsyndrome ,HRS)是严重肝病、肝硬化和门静脉高压患者晚期出现的一种功能性、肾前性急性肾功能不全,预后差,死亡率高。其主要病理生理特征是内源性血管活性物质异常引起肾外全身动脉扩张和循环血量不足,导致肾血管显著收缩和肾小球滤过率(GFR)骤然下降。 Hepatorenal syndrome (hepatorenal syndrome, HRS) is a functional, prerenal acute renal insufficiency in patients with severe liver disease, cirrhosis and portal hypertension with poor prognosis and high mortality. The main pathophysiologic feature is the abnormality of endogenous vasoactive substances, which leads to the extrarenal systemic arterial dilatation and lack of circulating blood volume, resulting in a significant decrease of renal vessels and glomerular filtration rate (GFR).