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目的 探讨CT导向下经皮穿刺椎体活检技术及其对椎体病变定性诊断的价值.资料与方法 62例椎体病变患者,男45例,女17例,单椎体病变38例,两椎体病变14例,多椎体病变10例.其中颈椎2例,胸椎28例,腰椎25例,骶尾椎7例.颈椎病变患者取仰卧位,胸、腰、骶椎病变患者取俯卧位.在CT横断扫描导向下,对病变部位穿刺活检,穿刺标本送病理学检查.结果62例患者均穿刺成功,52例(80.8%)成功取得病理组织并得到明确的病理结果,6例未取得病理组织,3例病理诊断不明确,1例不相符.行免疫组织化学检查10例,得到了明确的组织学诊断,4例恶性病变因细胞组织太少仍不能明确组织学特征.结论 CT引导下椎体穿刺活检术,具有微创、安全、取材准确、可靠、方便等优点,是脊柱病变活检的理想方法 ,可以为临床提供可靠的组织学依据.“,”Objective To explore the technology and diagnostic value of CT-guided pereutaneons biopsy for the spine lesions.Materials and Methods Sixty-two cases of patients(45 male,17 female) with the spine lesion underwent CT-guided percutaneous biopsy.The spinal lesions involved single vertebra in 38 eases ,two vertebrae in 14 cases,and multiple vertebral in 10 eases.The localization of lesions were cervical vertebra in 2 eases,thoracic vertebra in 28 eases,lumbar vertebra in 25 and sacral vertebra in 7 eases.Precise needle paths were designed according to CT images.The biopsy spec-imens were further histologically examed.Results Adequate specimens for pathologic examination were obtained in 52 of 62 cases (80.8%).The remaining 10 eases included no specimen be obtained(6 eases) ,uncertainty pathological diagno-sis (3 eases) and discordancy (1eases).Clear histological diagnosis was obtained after I mmunohistochemistry examination in 10 cases.Conclusion CT guided pereutaneous biopsy is a minimally invasive,safe and reliable tool in the evaluation of spinal lesions.