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线粒体具有电子传递系统。通过电子传递系统的氧化还原作用,线粒体成为细胞呼吸的主要处所。然而并非所有的细胞氧化作用均发生于这一细胞器。作者们的研究证明线粒体外氧化系统——过氧化物酶体(Peroxisome,过氧化氢酶和α-羟酸氧化酶)对豚鼠耳蜗代谢具有重要作用。氏等首次用细胞化学方法观察了豚鼠耳蜗过氧化物酶体的分布及其超微结构。研究了过氧化物酶体所催化的两个独立生物化学反应。过氧化氢酶分子为一四聚体,带有一个正铁血红素侧位辅基。正铁血红素所含之铁与细胞(胞浆)的过氧化氢(H_2O_2)形成复合物。铁·
Mitochondria have an electron transfer system. Mitochondria become the main site for cellular respiration through the redox action of the electron transport system. However, not all cellular oxidation occurs in this organelle. The authors’ studies demonstrate that mitochondrial extracorporeal oxidation systems, peroxisomes (peroxisomes, catalases and alpha-hydroxy acid oxidases), play an important role in cochlear metabolism in guinea pigs. For the first time by cytochemistry observed guinea pig cochlea peroxisome distribution and ultrastructure. Two independent biochemical reactions catalyzed by peroxisomes were studied. The catalase molecule is a tetramer with a heme-flanking prosthetic group. Iron contained in heme forms complexes with hydrogen peroxide (H 2 O 2) in cells (cytoplasm). iron·