论文部分内容阅读
Objective:To determine the bioinformatical characteristics of differential gene expression in patients with chronic superficial gastritis(CSG) with the Pi-deficiency syndrome(PDS) and those of the non-Pi -deficiency syndrome(non-PDS),i.e.patients of CSG with Pi(脾)-Wei(胃) dampnese-heat syndrome and healthy persons.Methods:With the BRB-Array Tools software package,original data collection and bioinformatic analysis of gene arrays were conducted in 6 CSG patients of PDS(CSG-PDS),6 CSG patients of non-PDS (CSG-nPDS),and 6 healthy volunteers(Normal).Results:Compared with non-PDS,the gene expressions in PDS with regards to protein synthesis,energy metabolism,immune reaction and ionic transport tended to be down-regulated,while those concerning secretion,cytoskeleton and ubiquitinization were up-regulated dominantly.Conclusions:The two kinds of samples,CSG-PDS/Normal and CSG-PDS/CSG-nPDS,have their respective gene expression profiles with different characteristics.Gene expression profile has certain referential significance in syndrome classification.
Objective: To determine the bioinformatical characteristics of differential gene expression in patients with chronic superficial gastritis (CSG) with the Pi-deficiency syndrome (PDS) and those of the non-Pi-deficiency syndrome (non-PDS), iepatients of CSG with Pi (spleen) -Wei (stomach) dampnese-heat syndrome and healthy persons. Methods: With the BRB-Array Tools software package, original data collection and bioinformatic analysis of gene arrays were conducted in 6 CSG patients of PDS (CSG-PDS) , 6 CSG patients of non-PDS (CSG-nPDS), and 6 healthy volunteers (Normal). Results: Compared with non-PDS, the gene expressions in PDS with regards to protein synthesis, energy metabolism, immune reaction and ionic transport tended to be down-regulated, while those concerning secretion, cytoskeleton and ubiquitinization were up-regulated dominantly. Conclusions: The two kinds of samples, CSG-PDS / Normal and CSG-PDS / CSG-nPDS, have their respective gene expression profiles with different characteristics.Gene expression profile has certain referential significance in syndrome classification.