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血栓性血小板减少性紫癜(thrombotic thrombocytopenic purpura,TTP)又称Moschcowitz综合征。1924年由Moschcowitz首先描述。1947年Singer首先使用TTP的病名,一直沿用至今。本病病因未明,可能与感染、中毒、妊娠、雌激素和孕酮、药物、结缔组织病、恶性肿瘤、家族因素、免疫因素、血浆中存在血小板聚集因子而缺乏血小板凝集因子抑制素、血浆中前列环素(PGI_2)降解加速等有关。上述因素可引起血小板在微血管中沉积,形成玻璃样微血检。至于原发损害是在血小板抑
Thrombotic thrombocytopenic purpura (TTP), also known as Moschcowitz syndrome. Described first by Moschcowitz in 1924. Singer first used the name of TTP in 1947 and has been in use ever since. The etiology of this disease is unknown, may be associated with infection, poisoning, pregnancy, estrogen and progesterone, drugs, connective tissue disease, malignancies, familial factors, immune factors, the presence of platelet aggregation factor in plasma and the lack of platelet aggregation factor inhibin, plasma Prostacyclin (PGI_2) accelerated degradation and so on. The above factors can cause platelet deposition in the microvascular to form a glass-like micro-blood test. As for the primary damage is in platelets