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骨质疏松症是遗传和环境因素共同参与的多因子复杂疾病。维生素D受体基因被认为是调控骨量的候选基因之一,但维生素D受体基因多态性与骨质疏松症(骨密度和骨质疏松性骨折两个表型)的关系在不同种族人群的研究仍存在争议,本文就维生素D受体基因多态性与骨质疏松症的关系予以综述。
Osteoporosis is a complex, multifactorial disease involving both genetic and environmental factors. Vitamin D receptor gene is considered to be one of the candidate genes regulating bone mass, but the relationship between vitamin D receptor gene polymorphism and osteoporosis (bone mineral density and osteoporotic fracture two phenotypes) in different races The research on population is still controversial. This article reviews the relationship between vitamin D receptor gene polymorphism and osteoporosis.