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Objective:To investigate the changing trends of clinical management for severe acute pancreatitis(SAP) with integrative medicine.Methods:Clinical data of 1 561 patients with SAP from 1980 to 2005 was retrospectively analyzed.The mortality and morbidity of complications were compared.Results:Of the 1 561 patients,400 patients accepted surgical operation,while the rest were treated conservatively with integrative medicine.There was a change toward conservative management together with Chinese purgative herbal medication use after 1990(22.4%from 1980-1990 compared with 45.5%from 1991-1993) because of high postoperative mortality.From 1994-2005,the treatment integrating Western medicine with Chinese herbal medications came to be preferred over the classic Western operation-based method.This change was associated with decreased morbidity(35.4%in 1980-1990 compared with 24.7%in 1991-1993 and 11.0%in 1994-2005,P<0.05) and lower mortality(40.52%of 1980-1990 compared with 17.17%of 1991- 1993 and 10.25%of 1994-2005,P<0.05).Conclusion:The combination of conservative management with Chinese herbal medicines is preferable to classic Western medicine treatment to reduce morbidity and mortality of SAP,while surgery becomes a supplemental option.
Objective: To investigate the changing trends of clinical management for severe acute pancreatitis (SAP) with integrative medicine. Methods: Clinical data of 1 561 patients with SAP from retrospectively analyzed from 1980 to 2005. The mortality and morbidity of complications were compared. Results: Of the 1 561 patients, 400 patients accepted surgical operation, while the rest were treated conservatively with integrative medicine. There was a change to conservative management together with Chinese purgative herbal medication use after 1990 (22.4% from 1980-1990 compared with 45.5% from 1991-1993) because of high postoperative mortality. From 1994-2005, the treatment integrating Western medicine with Chinese herbal medications came to be preferred over the classic Western operation-based method. This change was associated with decreased morbidity (35.4% in 1980- 1990 compared with 24.7% in 1991-1993 and 11.0% in 1994-2005, P <0.05) and lower mortality (40.52% of 1980-1990 compared with 17.17% of 1991-1993 an d 10.25% of 1994-2005, P <0.05) .Conclusion: The combination of conservative management with Chinese herbal medicines is preferable to classic Western medicine treatment to reduce morbidity and mortality of SAP, while surgery becomes a supplemental option.