论文部分内容阅读
本文根据经验的多原子分子间相互作用势研究了氨基酸的遗传密码子与反密码子的相互识别。我们以RNA12的几何构型为理论模型,计算了RNA12上互补碱基间,非互补碱基间和碱基三联体间的相互作用能,并对碱基异构体参与的非互补碱基配对的相互作用能函数进行了自选尺度拟牛顿法的最优化处理.研究结果可归纳如下:1.从分子间相互作用能的角度阐明了氨基酸遗传密码子与反密码子配对的wobble学说。并指出,当存在一定自由度时密码子的第三个碱基U能与反密码子中碱基G、I的醇式异构体配对,而密码子的第三个碱基A能以顺式构象与反密码子中碱基I配对,并求得它们的最优配位模式。2.现有的大多数密码子和反密码子间的识别关系可由它们之间的相互作用能来说明,从而进一步阐明了密码子与反密码子中碱基间直接的物理的相互作用在密码子与反密码子的高度专一性识别过程中起着重要的作用。
In this paper, the mutual recognition of amino acid codons and anticodons was studied based on the experience of polyatomic interaction potential. Based on the geometry of RNA12, we calculated the interaction energies of complementary bases, non-complementary bases and triplet bases of RNA12, and calculated the interaction between base non-complementary base pairs Newton’s method is studied in this paper.The results of the research are summarized as follows: 1. The wobble theory of the pairing between amino acid codon and anticodon is elucidated from the perspective of the intermolecular interaction energy. And pointed out that when there is a certain degree of freedom, the third base of the codon U can counter codon base G, I alcohol isomer pairing, and the third codon A base to cis The conformation is paired with the base I in the anticodon and the optimal coordination mode is obtained. 2. Most existing codon and anti-codon recognition relationship can be explained by the interaction between them to further clarify the direct physical interaction between codons and anti-codon base in the password The highly specific recognition of sub-and anti-codons plays an important role.