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本实验观察了低体温动物缺氧性肺血管收缩反应(HPV)的变化,同时对低体温前后动脉血浆去甲肾上腺素(NE)、TxB_2(TXA_2稳定代谢产物)和6—ket0—PGF_(1α)(PGI_2稳定代谢产物)、5—羟色胺(5—HT)、5—羟吲哚乙酸(5—HIAA)的含量进行了测定。结果发现:低体温时HPV明显增强,由低温前34.7±5.8％上升至57.6±6.8％(p<0.05)。哌唑嗪可以抑制其反应,用药后HPV为23.5±11.9％。低体温及低体温缺氧均可增加血浆NE浓度,两
In this study, we observed the changes of hypoxic pulmonary vasoconstriction (HPV) in hypothermia animals before and after hypothermia, and the effects of norepinephrine (NE), TxB 2 (TXA 2 stable metabolites) and 6-keto-PGF 1α ) (PGI-2 stable metabolites), 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were determined. The results showed that: HPV at low body temperature increased significantly from 34.7 ± 5.8% before hypothermia to 57.6 ± 6.8% (p <0.05). Prazosin can inhibit the reaction, after taking HPV 23.5 ± 11.9%. Hypothermia and hypothermia hypoxia can increase plasma NE concentration, two