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目的探讨正常体质量代谢性肥胖(MONW)与代谢综合征的相关性,寻找代谢综合征早期防治切点。方法选择湛江师范学院1406名教职工为研究对象,进行生活方式调查和身高、体质量、血压、腹部和颈血管彩超、经颅多普勒、心电图、血生化等检测。MONW组分别与正常体质量组、肥胖组的相关病症进行比较,对代谢综合征的影响因素进行logistic回归分析。结果湛江师范学院教职工MONW检出率为18.5%,其中男性为24.4%,女性为14.4%,男性明显高于女性(χ2=22.9,P<0.01)。MONW组血脂异常、高血压、高尿酸血症、颈动脉硬化或斑块、糖调节受损或糖尿病、冠心病和代谢综合征检出率均高于正常体质量组(P<0.05);除颈动脉硬化或斑块、冠心病的检出率与肥胖组差异无统计学意义(P>0.05),其他相关病症检出率均低于肥胖组(P<0.05)。logistic回归分析显示,MONW和肥胖发生代谢综合征的危险性较正常体质量者增加9~12倍。结论 MONW已成为高校知识分子群体的主要慢性病,也是代谢综合征的主要危险因素,可作为代谢综合征早期防治的观测指标。高校知识分子不良的生活方式和环境值得关注。
Objective To investigate the relationship between normal body mass metabolic obesity (MONW) and metabolic syndrome and to search for the early prevention and treatment of metabolic syndrome. Methods 1406 teachers and staffs in Zhanjiang Teachers College were chosen as the research objects. The life style survey and height, body mass, blood pressure, abdominal and cervical vascular ultrasound, transcranial Doppler, electrocardiogram and blood biochemistry were performed. MONW group were compared with the normal body mass group, obesity group related conditions, the impact of metabolic syndrome factors logistic regression analysis. Results The detection rate of MONW in staff of Zhanjiang Normal College was 18.5%, of which 24.4% were male and 14.4% were female, which was significantly higher in males than in females (χ2 = 22.9, P <0.01). The incidence of dyslipidemia, hypertension, hyperuricemia, carotid atherosclerosis or plaque, impaired glucose regulation or diabetes mellitus, coronary heart disease and metabolic syndrome in MONW group were higher than those in normal body mass group (P <0.05) The detection rate of carotid atherosclerosis or plaque and coronary heart disease was not significantly different from that of obesity group (P> 0.05). The detection rates of other related diseases were lower than those of obesity group (P <0.05). Logistic regression analysis showed that the risk of metabolic syndrome in MONW and obesity increased by 9 to 12 times than normal body mass. Conclusion MONW has become a major chronic disease in college intellectuals and is also a major risk factor for metabolic syndrome. It may be used as an indicator of early prevention and treatment of metabolic syndrome. The unhealthy lifestyle and environment of intellectuals in colleges and universities deserve attention.