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采用形态计量学的方法分析了游泳耐力训练后中药锁阳对大鼠小脑Ｐｕｒｋｉｎｊｅ细胞线粒体超微结构的影响，探讨了锁阳提高机体运动能力方面的作用。方法：ＳＤ雄性大鼠３２只，随机分成４组，即对照组，游泳组，锁阳对照组，游泳兼喂锁阳组。游泳的两组进行连续１２周的游泳耐力训练。结果：游泳的两组大鼠小脑Ｐｕｒｋｉｎｊｅ氏细胞线粒体发生了明显的形态学变化，数目增多，体积增大，嵴致密，基质电子密度增高，但游泳组大鼠线粒体部份发生了损伤性变化。而游泳兼喂锁阳的大鼠小脑Ｐｕｒｋｉｎｊｅ氏细胞线粒体未见有退行性变化。进一步形态计量学分析游泳组和游泳兼喂锁阳组大鼠小脑Ｐｕｒｋｉｎｊｅ氏细胞线粒体体密度、面密度、数密度均比对照组和锁阳对照组增大Ｐ＜０．０５，而游泳兼喂锁阳组的体密度比游泳组降低，比表面比游泳组的增大Ｐ＜０．０５。结论：中药锁阳能够改善小脑Ｐｕｒｋｉｎｊｅ氏细胞线粒体的损伤性变化，进一步提高细胞的整体能量代谢水平，防止运动性疲劳的过早出现。
The effect of Cynomorium cremoris on the mitochondrial ultrastructure of Purkinje cells in cerebellum of swimming rats after swimming endurance training was analyzed by using morphometric method, and the effect of Cynomorium mongholicus on improving body movement was discussed. Methods: Thirty-two SD male rats were randomly divided into 4 groups: control group, swimming group, Cynomorium control group, swimming group and Cynomorium group. Swimming two consecutive 12-week swimming endurance training. Results: There were obvious morphological changes in mitochondria of Purkinje’s cells in the swimming groups. The number increased, the volume increased, the crest became dense and the electron density of the matrix increased. However, the mitochondrial part of swimming rats had some damage changes. However, there was no degenerative change in the mitochondria of Purkinje’s rat cerebellum swimming and feeding Cynomorium. Further morphometric analysis showed that the body density, surface density and density of Purkinje cells in swimming group and swimming group were higher than those in control group and Cynomorium control group (P <0.05) The body density of Cynomorium group was lower than that of swimming group, and the specific surface area was higher than that of swimming group (P <0.05). Conclusion: Cynomorium can improve the damage of mitochondria in Purkinje cells and further improve the overall energy metabolism of the cells and prevent the premature appearance of exercise-induced fatigue.