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近年来的研究发现,各种实验性癫痫发作可诱导成年啮齿类动物脑内的神经元产生。癫痫发作如何诱导神经元的发生及新生的神经元在癫痫发生中的作用尚未明了。现有证据表明,癫痫发作诱导的神经元产生除与发作引起的细胞死亡释放的生长因子有关外,5-羟色胺受体激活可能是癫痫发作诱导齿状回处细胞增殖和存活的关键步骤。癫痫脑齿状回内神经元发生的改变,可能是病理性的并且促进了过度兴奋性的形成,也可能是与慢性癫痫相关的记忆障碍的原因。
Recent studies have found that various experimental seizures can induce neuronal production in adult rodent brains. How epileptic seizures induce the occurrence of neurons and the role of newborn neurons in epilepsy is unclear. The available evidence indicates that in addition to the growth factors induced by seizure-induced cell death, the activation of serotonin receptors may be the key step in seizure-induced cell proliferation and survival in the dentate gyrus. Changes in the neurons of the neurons in the brainstem of the epileptic brain may be pathological and promote the formation of hyperatimulation and may also be the cause of memory disorders associated with chronic epilepsy.