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目的检测了乙型脑炎患者血清和脑脊液中可溶性白细胞介素2受体（sIL－2R）变化。方法采用双抗体夹心ELISA法。结果发现乙型脑炎患儿血清及脑脊液白细胞介素2受体在急性期明显升高，恢复期脑脊液sIL－2R明显下降。结论脑脊液中可溶性白细胞介素2受体检测及动态变化有助于了解预后。同时也是临床区别颅内外感染的简便有效的指标之一。
Objective To detect the changes of soluble interleukin 2 receptor (sIL-2R) in serum and cerebrospinal fluid (CSF) of Japanese encephalitis patients. Methods Double antibody sandwich ELISA was used. The results showed that children with encephalitis B serum and cerebrospinal fluid interleukin 2 receptor was significantly increased in acute phase, recovery of cerebrospinal fluid sIL-2R decreased significantly. Conclusions The detection and dynamic changes of soluble interleukin-2 receptor in cerebrospinal fluid may help to understand the prognosis. It is also one of the simple and effective indicators of the clinical difference between intracranial and extracranial infections.