50年代发现锂对躁狂抑郁症及精神分裂症有疗效,以后其应用范围日趋扩大。新近尚有用于甲状腺机能亢进及慢性红斑性面痛治疗。作者报道2例曾长期以锂治疗无不良反应,疗效良好的患者发生重度不可逆性小脑损害。例1:女,42岁,因意识障碍逐渐加重急诊入院。患者患躁狂抑郁症已20年。近两年用锂治疗(Lithiofor(?)660mg每日2次),服药期间无不良反应,病情缓解。定期查血锂水平常为0.7～0.8mmol/L。约在入院前3周,患者不知何故自行增加用量(660mg每日3次)。入院前1周有多尿、烦渴、震颤及共济失调。体检患者四肢对称性运动,双侧反射活跃。血锂水平3.4(正常值1.5)mmol/L,脑脊液无明显变化,血肌酐及钠呈一时性增高。患者昏迷13天。入院2天后复查血锂2.5mm01/L,1周后0.05mmol/L。2周后见明显脑-锥体外系综合征,眼球震颤,重度构音障碍,头震颤,躯干和四肢共济失调,指鼻和跟膝试验不准,回跳征阳性、肌张力低。入院第10 In the 1950s, lithium was found to be effective in manic depression and schizophrenia, and its scope of application has been expanding ever since. Newly used for hyperthyroidism and chronic erythematous facial pain treatment. The authors report that 2 patients who had long been treated with lithium had no adverse reactions and that patients with good outcomes had severe irreversible cerebellar lesions. Example 1: Female, 42 years old, due to disturbance of consciousness Gradually increased emergency admission. Patients suffering from manic depression has been 20 years. The past two years with lithium treatment (Lithiofor (?) 660mg twice daily), no adverse reactions during the medication, the disease eased. Check the level of lithium regularly is 0.7 ~ 0.8mmol / L. About 3 weeks before admission, patients somehow increase their own dosage (660mg 3 times a day). One week before admission, there is polyuria, polydipsia, tremor and ataxia. Physical examination of patients with symmetrical limb movements, bilateral reflex activity. Blood lithium level 3.4 (normal 1.5) mmol / L, no significant changes in cerebrospinal fluid, serum creatinine and sodium was temporarily increased. Patients coma for 13 days. Two days after admission, blood lithium 2.5mm01 / L, 0.05mmol / L after one week. After 2 weeks, there were obvious brain-extrapyramidal syndromes, nystagmus, severe dysarthria, head tremor, ataxia of the trunk and limbs, inaccurate nasal and knee tests, positive bounce signs, and low muscle tone. Admission the 10th