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目的：比较~(８９)Ｓｒ和~(１５３)Ｓｍｉｎ－ＥＤＴＭＰ治疗鼻咽癌（ｎａｓｏｐｈａｒｙｎｇｅａｌ ｃａｒｃｉｎｏｍａ， ＮＰＣ）多发性骨转移瘤的疗效。方法：从１９９７年５月到１９９９年３月，作者用~(８９)Ｓｒ和~(１５３)Ｓｍ－ＥＤＴＭＰ分别治疗ＮＰＣ多发性骨转移瘤病人４５例和６８例。根据治疗前后骨痛缓解和生活质量的情况决定疗效，同时比较其病灶摄取放射性变化，观察开始起效的时间，对病人血清ＶＣＡ－ＩｇＡ、ＥＡ－ＩｇＡ水平和骨髓造血功能的影响。结果：~(８９)Ｓｒ和~(１５３)Ｓｍ－ＥＤＴＭＰ治疗ＮＰＣ多发性骨转移瘤的有效率分别为 ８６． ７％和 ８８.２％，治疗后起效的时间为 １１.０和 ７.２天；治疗前后和两组骨转移灶 ＲＯＩ值变化、对 ＮＰＣ病人血清 ＶＣＡ－ＩｇＡ、ＥＡ－ＩｇＡ水平和外周血相的影响有显著性差别（ Ｐ＜ ０．０５）。结论：~(８９)Ｓｒ和~(153)Ｓｍ－ＥＤＴＭＰ对 ＮＰＣ骨转移病人的疼痛缓解和生活质量的提高有肯定疗效。~(１５３)Ｓｍ－ＥＤＴＭＰ对ＮＰＣ骨转移灶的抑制作用明显强于~(８９)Ｓｒ，可以部分降低ＶＣＡ－ＩｇＡ和ＥＡ－ＩｇＡ水平。～（１５３）Ｓｍ－ＥＤＴＭＰ的骨髓毒性较~(８９)Ｓｒ严重。
Objective: To compare the efficacy of ~ (89) Sr and ~ (153) Smin-EDTMP in the treatment of multiple bone metastases of nasopharyngeal carcinoma (NPC). Methods: From May 1997 to March 1999, the authors treated 45 and 68 patients with multiple bone metastases of NPC with ~ (89) Sr and ~ (153) Sm-EDTMP, respectively. The curative effect was determined according to the relief of pain and quality of life before and after treatment. At the same time, the change of uptake of radioactivity in the lesion and the onset time were observed. The effects on serum VCA-IgA, EA-IgA and bone marrow hematopoietic function were also observed. Results: The effective rates of ~ (89) Sr and ~ (153) Sm-EDTMP in the treatment of multiple bone metastases of NPC were 86% and 86%, respectively. 7 and 88.2%, respectively. The onset time after treatment was 11.0 and 7.2 days respectively. The changes of ROI in bone metastases before and after treatment and the changes of serum VCA-IgA, EA-IgA and peripheral Blood effects were significantly different (P <0.05). Conclusion: The positive effects of ~ (89) Sr and ~ (153) Sm-EDTMP on pain relief and quality of life in NPC patients with bone metastases are confirmed. The inhibitory effect of ~ (153) Sm-EDTMP on NPC bone metastases was significantly stronger than that of ~ (89) Sr, which could partially reduce the levels of VCA-IgA and EA-IgA. The myelotoxicity of ~ (153) Sm-EDTMP was more severe than that of ~ (89) Sr.