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目的判定脑钠素(BNP)在评价冠心病(CHD)患者行经皮冠状动脉介入治疗(PCI)改善心功能中的价值。方法测定连续43例成功接受PCI的CHD患者术前及术后第4天晨血浆BNP及超声心动图(UCG)室壁运动情况、左室射血分数(LVEF)、短轴缩短分数(FS)、舒张早期充盈峰的最大速度(E峰)、舒张晚期充盈峰的最大速度(A峰)及E/A。结果43例冠心病患者总体PCI术前及术后第4天UCG的变化不明显(P>0.05);而PCI术后第4天BNP较术前显著下降(P<0.05),特别是心肌梗死组(尤其是前壁心梗组)、室壁运动异常组、左室扩大组、心功能不全组、三支病变组、冠状动脉严重狭窄组、罪犯血管再通组术后BNP较术前BNP下降更明显(P<0.05)。结论BNP评价PCI的近期疗效优于UCG,可作为评价PCI术改善心功能近期疗效的敏感指标。
Objective To determine the value of BNP in evaluating cardiac function in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). Methods Plasma BNP and echocardiography (UCG) wall motion, left ventricular ejection fraction (LVEF), short axis fractional shortening (FS), and left ventricular ejection fraction were measured in 43 consecutive patients with CHD who were successfully treated with PCI. , Peak diastolic filling velocity (E peak), maximal diastolic filling velocity (A peak) and E / A. Results The change of UCG in 43 patients with coronary heart disease before PCI and on the 4th day after PCI was insignificant (P> 0.05). On the 4th day after PCI, the BNP decreased significantly (P <0.05), especially myocardial infarction Group (especially the anterior myocardial infarction group), abnormal wall motion group, left ventricular enlargement group, cardiac dysfunction group, three lesions group, severe coronary artery stenosis group, cripple recanalization group postoperative BNP than preoperative BNP Decreased more significantly (P <0.05). Conclusions BNP is superior to UCG in evaluating the short-term efficacy of PCI. It can be used as a sensitive index to evaluate the short-term efficacy of PCI in improving cardiac function.