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胶原病是结缔组织的炎性改变为主的全身性疾病,可累及全身所有脏器。神经症状是常见的,而类似神经症状的发病机理因疾病和病情的不同而异。现将与胶原病相关的神经症状的发病机理分类如下:①胶原病变本身累及了神经系统;②胶原病引起其他脏器衰竭导致继发性神经系统病变(高血压、肾衰、肝功不全,骨变形、甲状腺低功等);③药物的副作用(肾上腺皮质激素、抗痉挛剂等);④合并其他神经疾病(感染、多发性硬化症、重症肌无力、脑血管障碍等)。在临床上以上述原因引起的神经症状较为多见,但是确认其中主要原因,对治疗效果有重要意义。本文以累及神经系统为重点做如下讨论。
Collagen disease is a systemic disease characterized by inflammatory changes of connective tissue that can affect all organs of the body. Neurological symptoms are common, and the pathogenesis of similar neurological symptoms varies with disease and condition. The pathogenesis of neurological symptoms associated with collagen disease is now categorized as follows: (1) Collagen lesions itself involve the nervous system; (2) Collagenopathy causes other organ failure leading to secondary neurological disorders (hypertension, renal failure, hepatic insufficiency, Bone deformity, low thyroid gland, etc.); ③ drug side effects (adrenal cortex hormones, anticonvulsants, etc.); ④ combined with other neurological diseases (infections, multiple sclerosis, myasthenia gravis, cerebrovascular disorders, etc.). Neurological symptoms caused by the above reasons are more common in clinical practice, but it is of great significance to confirm the main reason for the treatment effect. This article focuses on the nervous system involvement as discussed below.