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P物质的生理作用,主要表现在神经系统和心血管系统二方面,前者已有专文讨论;后者在国内期刊还未见介绍。本文对P物质在心血管系统的作用做一简介。一、降血压1931年von Euler从牛脑和肠提取出一种未知物质,发现它能降低动物的血压。当动脉或静脉注入部分纯的P物质或P物质的纯品,都能引起短时间的血压降低。降压作用适用于禽类、所有哺乳动物和人。降压效用的高低因动物的种属而异,对兔和狗引起降压的P物质阈剂量比猫和老鼠低,通常3～5个单位的P物质就能使兔子降压20毫米汞柱。使猫达到该降压值则需要20～30单位,所以常用兔,特别是用狗作实验对象。P物质对猴和人也能降压。
The physiological role of substance P is mainly manifested in the two aspects of the nervous system and cardiovascular system, the former has been discussed in the article; the latter has not yet been introduced in domestic journals. This article gives an introduction to the role of substance P in the cardiovascular system. First, lower blood pressure In 1931, von Euler extracted from the bovine brain and intestine of an unknown substance, found that it can lower blood pressure in animals. When arterial or intravenous injection of a portion of pure substance P or substance P can cause short-term blood pressure reduction. Antihypertensive effect for poultry, all mammals and humans. The level of antihypertensive utility depends on the species of animal, and the threshold dose of substance P that causes depressurization in rabbits and dogs is lower than in cats and mice, typically 3 to 5 units of substance P can depress the rabbit by 20 mmHg . The cat to achieve the value of the blood pressure you need 20 to 30 units, so commonly used rabbits, especially dogs as experimental subjects. Substance P can also lower blood pressure in monkeys and humans.