慢性丙型肝炎病毒(HCV)感染是伴随多器官损害的慢性肝脏疾病。混合性冷球蛋白血症综合征(MCS)最为常见,可引起皮肤、肾脏、神经系统、血液系统、血管系统等多系统器官受累。IFN-α治疗可加重HCV相关性神经病变,故在选择治疗方案时应充分考虑受累器官的部位、损害的严重程度等多方因素,进行个体化治疗。本文就MCS发病机制、临床表现、诊断和治疗的进展做一综述。 Chronic hepatitis C virus (HCV) infection is a chronic liver disease with multiple organ damage. Mixed cryoglobulinemia syndrome (MCS) is the most common, can cause skin, kidneys, nervous system, blood system, vascular system and other multi-system organ involvement. IFN-α therapy can aggravate HCV-related neuropathy, so in the choice of treatment options should take full account of the affected organs, the severity of the damage and other factors, the individual treatment. This article reviews the pathogenesis, clinical manifestations, diagnosis and treatment of MCS.