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本文对加味黄芪建中湯的抗大白鼠胃溃疡作用及毒性作了初步探讨.建中湯煎剂给大白鼠皮下注射10克/公斤,可防止幽门结扎所致胃溃疡的发生;还能抑制胃液分泌、减少游离酸和总酸度;并使胃液pH值上升.但灌胃给药25克/公斤则不能防止溃疡的发生.建中湯煎剂对鸽胃正常运动及家兔腸运动都有抑制作用,并在一定程度上能对抗乙酰胆碱和毛果云香碱所致的腸痉挛.建中湯煎剂给小白鼠皮下注射的LD_(50)为48±7.2克/公斤.
In this paper, preliminary study was made on the effect and toxicity of Jiawei Huangqi Jianzhong Decoction against rat stomach ulcer. Jianzhong Decoction was injected subcutaneously into rats at 10g/kg to prevent the occurrence of gastric ulcer caused by pylorus ligation; it also inhibited gastric juice. Secretion, reduction of free acid and total acidity, and increase of gastric juice pH. However, gavage administration of 25 g/kg can not prevent the occurrence of ulcers. Jianzhong Decoction has inhibitory effects on the dovetail normal movement and rabbit intestinal movement. , And to a certain extent, can fight against acetylcholine and pilocarpine due to intestinal fistula. Jianzhongtang decoction subcutaneous injection of LD_ (50) for 48 ± 7.2 g / kg.