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多年来,芳香烃羟基化酶(AHH)的致癌作用己为人们所重视。本文回顾性研究了喉癌与 AHH 的诱发性和吸烟的关系。作者选择1960～1983年间在马尔摩总医院耳鼻喉科确诊的喉癌患者95例中的58例(其中声门癌48例、声门上癌10例)为对象,另以参与马尔摩预防计划的2111名健康者作对照。将研究组和健康对照组的 AHH 诱发水平都分为高、中、低三组,对 AHH诱发水平采用 Nebert 和 Gelboin 以及 Kellerman等的方法测定。其观测结果为:①58例中56例为嗜烟者,其中80％的吸烟量超过20支/日;②高、低 AHH 诱发水平的喉癌患者实际诱
Over the years, the carcinogenic effects of aromatase hydroxylase (AHH) have been valued. This article retrospectively studied the relationship between laryngeal cancer and AHH induced and smoking. The authors chose 58 patients (48 cases of supraglottic carcinoma and 10 cases of supraglottic carcinoma) of the 95 cases of laryngeal cancer diagnosed in Department of Otorhinolaryngology in Malmo General Hospital from 1960 to 1983 as their targets, and participated in the Malmo Prevention Program Of 2111 healthy people as a control. AHH-induced levels in study group and healthy control group were divided into high, medium and low groups, and the levels of AHH induced by Nebert and Gelboin and Kellerman et al. Were determined. The observations were as follows: ① Among the 58 cases, 56 were smokers, 80% of them smoked more than 20 cigarettes per day. ② The actual inducements of high and low AHH-induced laryngeal cancer patients