【摘 要】
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Dear Editor,Recently,type 2 diabetic patients were clinically observed to suffer from dysfunction not only in glucose metabolism,but also ribose[1-2].Ribose is
【机 构】
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Institute of Biophysics, Chinese Academy of Sciences,
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Dear Editor,Recently,type 2 diabetic patients were clinically observed to suffer from dysfunction not only in glucose metabolism,but also ribose[1-2].Ribose is rapidly reacted with protein[3-4],producing cytotoxic ribosylated products[5],whose progress is much faster than glucose[6-7].A 75 ku glucose regulated protein(GRP75)is generally recognized as a member of the heat shock protein 70(HSP70)class of proteins,which is induced under conditions of low glucose and other nutritional and environmental stresses[8-9].Administration of ribose induces a decrease in blood
Dear Editor, Recently, type 2 diabetic patients were clinically observed to suffer from dysfunction not only in glucose metabolism, but also ribose [1-2]. Ribose is rapidly reacted with protein [3-4], producing cytotoxic ribosylated products [5] , whose progress is much faster than glucose [6-7]. A 75 ku glucose regulated protein (GRP75) is generally recognized as a member of the heat shock protein 70 (HSP70) class of proteins, which is induced under conditions of low glucose and other nutritional and environmental stresses [8-9] .Administration of ribose induces a decrease in blood
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